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Sharma, Pramod Kumar
- Development and Validation of a RP-HPLC Method for Estimation of Thalidomide in Solid Dosage form
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PDF Views:2
Authors
Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), ID
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), ID
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 1 (2013), Pagination: 17-19Abstract
A simple, rapid and precise isocratic reverse phase High Performance Liquid Chromatographic method has been developed for the determination of Thalidomide capsule. The separation was achieved with 150×4.6mm C18 column using mobile phase as Acetonitrile: Dimethyl Formamide : Water (60:10:30 v/v) at a flow rate of 1.0ml/min with UV detection at 297nm. The retention time of Thalidomide was found to be 2.17min. The linearity range of Thalidomide is 25mg to 200mg with coefficient of correlation 0.9986. The method is found to be accurate, precise and useful in quality control of dosage form.Keywords
RP–HPLC, Thalidomide, Method Development and Validation
References
- Mellin GW, Katzenstoin M The Saga of Thalidomide- Neuropathy to Embryopathy, with Case Reports of Congenital Anomalies. New English Journal of Medicine. 267 (23); 1962: 1184-1193.
- Czejka MJ anf Koch HP Determination of thalidomide and its major metabolites by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 413; 1987: 181–187
- Youle M Clarbour J Farthing C Connolly M Hawkins D Staughton R and Gazzard B Treatment of resistant aphthous ulceration with thalidomide in patients positive for HIV antibody. British Medical Journal 432 (1); 1989: 298.
- Gorin I Vilette B Gehanno P and Escande JP Thalidomide in hyperalgic pharyngeal ulceration of AIDS. Lancet 335 (8701); 1990: 1343.
- Georghiou PR, Kemp RJ. HIV-associated esophageal ulcers treated with thalidomide. Medical Journal of Australia. 152; 1990:382-383.
- Radeff B Kuffer R Samson J. Recurrent aphthous ulcer in patient infected with human immunodeficiency virus: successful treatment with thalidomide. Journal of American Acadamy of Dermatol. 23; 1990:523-525.
- Li J Jaworsky MS and Stirling DI The determination of a potential impurity in Thalidomide drug substance and product by HPLC with indirect UV detection. Journal of Pharmaceutical and Bioedical Analysis. 31(1); 2003: 19-27.
- Toraño JS Verbon A Guchelaa HJ Quantitative determination of thalidomide in human serum with high-performance liquid chromatography using protein precipitation with trichloroacetic acid and ultraviolet detection. Journal of Chromatography B: Biomedical Sciences and Applications. 734(2); 1999: 203-210.
- Singh RM Shivraj Mathur SC Singh GN Sharma PK and Gupta SK Method development and its validation of Drug Thalidomide in API usinf RP-HPLC method. Journal of Indian Council of Chemist. 22(2); 2006: 25-27.
- Singh S Singh UK Singh RM Singh GN Mathur SC Saini PK Yadav A Gupta V and Duggal D Development and validation of a RP-HPLC method for estimation of prulifloxacin in tablet dosage form. Indian Journal of Pharmaceutical Science. 73(5); 2011: 557.
- Chen TL Vogelsang GB Petty BG Brundrett RB Noe DA Santos GW and Colvin OM Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers.Drug Metabolism Disposition 17; 1989: 402-405
- Shabir GA (2003) Validation of HPLC methods for pharmaceutical analysis: Understanding the differences and similarities between validation requirements of the U.S. Food and Drug Administration, the U.S. Pharmacopoeia and the International Conference on Harmonization. J Chromatogr A. 987; 57.
- International Conference on Harmonisation, (1996) Guidance for Industry In: Q2B Validation on Analytical Procedures. Methodology Switzerland IFPMA, 1.
- Development and Validation of a Spectrophometric Method for Estimation of Triamcinolone in Solid Dosage form
Abstract Views :404 |
PDF Views:0
Authors
Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 2 (2013), Pagination: 42-43Abstract
The new simple, sensitive, accurate, precise, rapid and economical method was developed for the estimation of Triamicinolone in solid dosage form. Method is based on the absorbance. Triamcinolone maximum is found at 238 nm in methanol water solvent. The linearity was obtained in the concentration range of 3-9 mcg/ml with coefficient of correlation 0.9998. The value of ruggedness and robustness was found to be 0.2182 and 0.43 respectively. The method is found to be accurate, precise and useful in quality control of dosage form.Keywords
Triamcinolone, Spectrophotometric and ValidationReferences
- Paganelli F Cardillo JA Oliveira AG Melo Jr LAS Skaf M Costa RA A single intraoperative sub–Tenon’s capsule triamcinolone acetonide injection for the treatment of post– cataract surgery inflammation. Ophthalmology 111;2004:2102-8.
- Cardillo JA Melo Jr LAS Costa RA Skaf M Belfort Jr R Souza- Filho AA Farah ME Kuppermann BD Comparison of intravitreal versus posterior sub-tenon’s capsule injection of triamcinolone acetonide for diffuse diabetic macular edema. Ophthalmology 112; 2005:1557-63.
- Magalhães E Nehemy P Santos DVV Fujji G Nehemy MB Avaliação clínica e incidência de endoftalmite infecciosa e nãoinfecciosa após injeção intravítrea de acetonida de triancinolona. Arq Bras Oftalmol. 69; 2006:791-4.
- Paganelli F, Cardillo JA, Melo Junior LA, Lucena DR, Silva- Júnior AA, Hofling AL, Nguye QD, Kuppermann BD, Belfort Junior R, Oliveira AG, A Single Intraoperative Sub-Tenons Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery. Invest Ophthalmol Vis Sci. 50; 2009:3041-7.
- Smith RG Burtner AP Oral side effects of the most frequently prescribed drug. Special Care in Dentistry. 14(3); 1994: 96- 102.
- Aquino GDA Stopilha RT Pedrosa, MFF Santos KSCR Egito EST Oliveira AG Silva-Junior AA Validation of quantitative analysis method for triamcinolone in ternary complexes by UVVis spectrophotometry. Rev Ciênc Farm Básica Application. 32(1); 2011: 35-40
- El-Saharty YS Hassan NY Metwally FH Simultaneous determination of terbinafine HCL and triamcinolone acetonide by UV derivative spectrophotometry and spectrodensitometry. Journal of Pharmacological and Biomedical Analysis 28(3- 4); 2002:569-80.
- Gupta SK Kumar B and Sharma PK Development and validation of a RP-HPLC method for estimation of Thalidomide in solid dosage form. Asian Journal of Pharmaceutical Analysis. 3(1); 2013: 17-19.
- Singh RM Shivraj Mathur SC Singh GN Sharma PK and Gupta SK Method development and its validation of Drug Thalidomide in API using RP-HPLC method. Journal of Indian Council of Chemist. 22(2); 2006: 25-27.
- Singh S Singh UK Singh RM Singh GN Mathur SC Saini PK Yadav A Gupta V and Duggal D Development and validation of a RP-HPLC method for estimation of prulifloxacin in tablet dosage form. Indian Journal of Pharmaceutical Science. 73(5); 2011: 557.
- International Conference on Harmonisation, (1996) Guidance for Industry in: Q2B Validation on Analytical Procedures. Methodology Switzerland IFPMA, 1.